Algodoo

A.K.A. Fat Man. It is a gun from Fallout 3. It doesn't have very good range so you're welcome to improve it. You can also try to make the explosion a mushroom cloud, because I couldn't really think of a way to do it. The instructions are with the scene. Here's a tip: After launching it, press undo twice (or until you undo the Sim Start) or it will tend to fail.

1-2 Edit: I gave it a makeover and made it so it doesn't explode so early, but doing so reduced range and effectivity.
1-3 Edit: I tweaked the options: Speed 2X and Gravity 3.20 m/s2. As well as some other things.